Is There a Connection Between Autoimmune Diseases and Hyperhidrosis?

This question comes up from time-to-time with patients who develop isolated excessive sweating later in their lives. These same patients have an autoimmune disease. The question that we often get is whether there is a connection between the two.

To our knowledge, there is no connection. One should remember that hyperhidrosis usually starts at an early age. There is also a genetic history in more than 50% of the cases. Autoimmune diseases typically start in the later years of someone’s life (40+).

The hallmark of typical hyperhidrosis is that the patient sweats from the waist down and from the ankles down. This very specific piece of information is missed by a lot of doctors who try to label those patients with an autoimmune disease.

These usually affect the whole body and not specific parts. This distinction is important, and not all doctors understand this. Autoimmune diseases are characterized by the discovery of certain markers in the blood. Hyperhidrosis patients have NO markers in their blood.


  1. Brenda  August 31, 2017

    My daughter is 14 and has suffered from hyperhydrosis since birth. She can barely hold a pencil without it slipping from her hand due to the sweat. Regards of the weather, she always wears a sweatshirt to soak up the sweat in the sleeve to avoid anyone at school from seeing it. Lately, her hands and feet will either be soaking wet or ice cold. I have three family members diagnosed with Raynaud’s Disease and my grandfather had scleroderma. I’m just curious if there is any connection between that and the hyperdrosis.

    • Center For Hyperhidrosis  September 1, 2017

      Hi Brenda. You have a good question. People with hyperhidrosis or excessive hands and feet sweating will also have cold and clammy hands on top of the sweating. The reason for the clammy extremities and the darker color of the extremities is because the increased sympathetic activity causing some narrowing of the blood vessels in the hands and feet. Many times those patients are labeled as the suffering from Raynaud`s which is not true. The fact that your grandfather suffered from scleroderma does not mean that you daughter has the same.
      For more information you can call 310-557-3037. Thanks


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