Hyperhidrosis and Genetics
As far as we know now genetics plays a major role in the cause of hyperhidrosis. Numerous studies based on large numbers of cases have shown a genetic history in more than 50% of the patients with hyperhidrosis. This incidence alone is enough of an indication that the basis for this problem is a genetic one. Researchers in China have found the location of the gene that affects this problem. Unfortunately gene manipulation or gene treatment is still a long way from being able to be used as a therapeutic measure. Dr. Reisfeld has treated and interviewed thousands of hyperhidrosis patients over the years and seen this genetic pattern time and time again in more than half of his patients. Dr. Reisfeld is one of the most experienced and respected hyperhidrosis surgeons in the world.
It should be known that the 50% + incidence rate is likely to be higher because people tend to not share or ignore the issue within their family. Hyperhidrosis is embarrassing condition and not likely to be talked about. A patient may have an uncle, aunt, nephew, niece etc who is also suffering from the condition but never know it.
Most of the patients who report some family history will more frequently say it is from the mother’s side of the family. We conducted an informal poll on our website and the results support this statement.
Major advances have been made in genetic research but due to the benign nature of hyperhidrosis less efforts by drug companies or researchers are given to solve this issue.