What is Drysol?

Drysol (aluminum chloride hexahydrate) is a prescribed medication used to treat hyperhidrosis. It is for those who suffer from excessive sweating, known medically as hyperhidrosis.

Prescription and Non-Prescription Strength
Aluminum salts such as aluminum chloride or aluminum chlorohydrate are the most commonly used topical treatments for hyperhidrosis. Over the counter antiperspirants containing aluminum chloride are available in varying concentrations. The maximum is usually 15% – 19%.

The metal complex produces a precipitation in the sweat gland ducts. These block the epidermal sweat duct or promote atrophy and vacuolization of the glandular secretory cells.

Higher concentrated solutions are available up to 25% with a prescription (Drysol, Xerac AC, Certain Dri). Studies with high concentrations have shown good results. In many cases, irritation, and a burning sensation are common side effects.

The patient puts on the solution at bedtime and washes it off 6-8 hours later. In order to get the maximum effect, gloves should be worn while covering the applied area.

Drysol: Long-Term Risks?

We do not know if there is a long-term risk when using aluminum chloride salts. There will be additional consideration for patients with kidney problems. We are aware that over the last several decades more questions have arisen about metallic compounds (prescribed and over the counter) in regards to their long-term safety.

Unfortunately, no known studies with accurate results are available. The disadvantages of these various lotions are the fact that they are used continuously to achieve the maximum results. Patients with severe cases of hyperhidrosis do not have a high ratio of success using these products.

Additional Information:
Learn about other Alternate Hyperhidrosis Treatments


  1. KK  January 6, 2017

    Can i use the Drysol ( Roll ) in my palms ?
    Or should it be cream ?

    • Center For Hyperhidrosis  January 6, 2017

      Drysol either in a cream or the a roll on are a good start to try and control hyperhidrosis. How effective it will be in the treatment of excessive hand sweating time will tell. Usually the level of success is very limited in those cases of severe hyperhidrosis.

  2. nyll  September 6, 2016

    is that available already here in the philippines?

    • Center For Hyperhidrosis  September 7, 2016

      I`m sure that in Manila you could find a surgeon who is familiar with the issue of the surgical treatment of hyperhidrosis.

  3. Vanessa Rios  May 10, 2016

    Is Xerac AC available over the counter or do I need a prescription?

    • Center For Hyperhidrosis  May 10, 2016

      Hi Vanessa. You have to check if the pharmacy can provide it without prescription. It is one of the Aluminum metallic compounds that is used to treat excessive sweating in the arm pits areas. You can try it and see how you react.Thanks

  4. Jordan  February 2, 2016

    Is DRYSOL really an effective answer for the excessive sweating?

    • Center For Hyperhidrosis  February 2, 2016

      Drysol is one of the conservative methods for the treatment of excessive hands and or arm pits(axillary) sweating. The success rate is higher when used to treat arm pit sweating. Overall the success with Drysol to treat excessive hand sweating is minimal. It is worth trying. Thanks

  5. dhan phungjeli  March 10, 2015

    Sir I get lots of sweat on my palm.. n in foot.. so plizzz help me how to stop it?? Because of this i cnt evn work , writing , play games, etc so plz help. Thnk u.

    • Center For Hyperhidrosis  March 10, 2015

      From your e mail I understand that you do not live in the US. You will have to find a doctor in your country who is familiar with the surgical treatment for excessive hands and feet sweating.Thanks

  6. Brenda Bailey  February 12, 2015

    ,need treatment for underarm sweat.

    • Center For Hyperhidrosis  February 12, 2015

      The best initial treatment for axillary hyperhidrosis are those anti antiperspirants that contain metallic compounds that contain aluminum chloride. Some can be obtained over the counter and some need to be given by a physician.You can read about those if you go back to the website sweaty-palms.com where you can read more about it.

      • Hail  March 13, 2015

        Hi do you know somewhere I can get a help? I am suffering to excessive palm, foot and mild on underarm sweating. Anywhere near green lake wisconsin. Thanks

        • Center For Hyperhidrosis  March 14, 2015

          Thanks for the comment Hail. I am not familiar with anyone in Wisconsin who is well versed with the topic of palmar and plantar hyperhidrosis and the surgical treatment of these problems. I will be very happy to answer your questions. Please call our office. (310) 557-3037.

      • Elizabeth  June 4, 2015

        Isn’t the aluminum and metallic compounds found in deoderants bad for the human body? Isn’t there a more natural treatment? Something not involving surgery, botox or other poisons?

        • Center For Hyperhidrosis  June 4, 2015

          You are right about metallic compounds that are found in Drysol and other deodorants. So far there are no definite data about the toxicity after long term use. In the market there are a lot of natural remedies but their efficiency is not proven. Botox also has a limited action. As far as now surgery is the long term answer for excessive hand and feet sweating.

  7. hermay  December 2, 2014

    i hope i can at least minimize the excessive sweating of my palm…

    • Center For Hyperhidrosis  December 6, 2014

      If you are a sufferer of excessive sweating (hyperhidrosis), we would be happy to speak with you further. Please contact us via phone at 310-557-3037.